Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Abstract The complexity of the tumor microenvironment (TME) severely hinders therapeutic effects various cancer treatment modalities. TME differs from normal tissues owing to presence hypoxia, low pH, and immune-suppressive characteristics. Modulation reverse growth equilibrium is considered an effective way treat tumors. Recently, polymeric nanomedicines have been widely used in therapy, because their synthesis can be controlled they are highly modifiable, demonstrated great potential remodel TME. In this review, we outline application stimuli responsive modulate TME, aiming provide insights for design next generation promote development therapy.